Prolonged quinidine half-life with associated toxicity in a patient with hepatic failure

Autor:	E J, Stanek, R J, Simko, D, DeNofrio, B B, Pavri
Rok vydání:	1997
Předmět:	Male Electrocardiography Long QT Syndrome Torsades de Pointes Atrial Fibrillation Humans Middle Aged Anti-Arrhythmia Agents Quinidine Liver Failure Half-Life
Zdroj:	Pharmacotherapy. 17(3)
ISSN:	0277-0008
Popis:	A markedly prolonged quinidine elimination half-life due to hepatic failure and resultant quinidine toxicity occurred in a 57-year-old man with a history of atrial fibrillation. A prolonged QT interval, development of torsades de pointes, and a serum quinidine concentration of 3.1 micrograms/ml contributed to a decision favoring permanent pacemaker implantation. The apparent quinidine half-life ranged from 66-99 hours and was associated with QT prolongation and persistent U waves. On discontinuing quinidine, all signs associated with toxicity resolved as serum quinidine concentrations decreased, which resulted in reversal of the decision to implant a permanent pacemaker. This case reports an extremely long quinidine elimination half-life and reillustrates the importance of drug pharmacokinetics in patient care.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ad6da0b60cea8816075e256e7cb8abda https://pubmed.ncbi.nlm.nih.gov/9165569 Zobrazit plný text záznamu Plný text