GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca

Autor:	Reshma, Ramracheya, Caroline, Chapman, Margarita, Chibalina, Haiqiang, Dou, Caroline, Miranda, Alejandro, González, Yusuke, Moritoh, Makoto, Shigeto, Quan, Zhang, Matthias, Braun, Anne, Clark, Paul R, Johnson, Patrik, Rorsman, Linford J B, Briant
Rok vydání:	2018
Předmět:	Adult Male endocrine system Exocytosis Membrane Potentials Signalling Pathways Calcium Channels Q-Type Mice Glucagon-Like Peptide 1 Membrane Physiology Animals Humans T2DM Type 2 diabetes mellitus Pancreas Cells Cultured Original Research KATP potassium ATP channel digestive oral and skin physiology Calcium Channels P-Type Middle Aged Calcium Channel Blockers Glucagon cAMP cyclic adenosine monophosphate Glucagon-Secreting Cells Female Endocrine and Metabolic Conditons Disorders and Treatments SST somatostatin hormones hormone substitutes and hormone antagonists GLP‐1 glucagon‐like peptide 1
Zdroj:	Physiological Reports
ISSN:	2051-817X
Popis:	Glucagon is the body's main hyperglycemic hormone, and its secretion is dysregulated in type 2 diabetes mellitus (T2DM). The incretin hormone glucagon‐like peptide‐1 (GLP‐1) is released from the gut and is used in T2DM therapy. Uniquely, it both stimulates insulin and inhibits glucagon secretion and thereby lowers plasma glucose levels. In this study, we have investigated the action of GLP‐1 on glucagon release from human pancreatic islets. Immunocytochemistry revealed that only
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ad598c1fdf414635b2531a9ebdd6a39c https://pubmed.ncbi.nlm.nih.gov/30187652 Zobrazit plný text záznamu Plný text