Role of Bicarbonate Supplementation on Urine Uric Acid Crystals and Diabetic Tubulopathy in Adults with Type 1 Diabetes: A Brief Report

Autor: Bjornstad, Petter, Maahs, David M., Roncal, Carlos A., Snell-Bergeon, Janet K., Shah, Viral N., Harra, Tamara, Ellis, Samuel L., Hatch, Matthew, Chung, Linh T., Rewers, Marian J., Garg, Satish, Cherney, David Z., Pyle, Laura, Nadeau, Kristen J., Johnson, Richard J.
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Popis: Uricosuria and crystallization are increasingly recognized risk factors for diabetic tubulopathy. This pilot clinical trial aimed to determine the acute effect of urinary alkalinization using oral sodium bicarbonate [NaHCO(3)] on UA crystals in adults with type 1 diabetes (T1D). Adults with T1D ages 18–65 years (n=45, 60% female, HbA1c 7.5±1.2%, 20.2±9.3 years duration) without chronic kidney disease (eGFR ≥60ml/min/1.73m(2) and albumin-to-creatinine ratio
Databáze: OpenAIRE