Decreased transcription, expression and function of low-density lipoprotein receptor in leukocytes from patients with systemic lupus erythematosus

Autor:	Liliana, Rivas, Mercedes, Zabaleta, Félix, Toro, Nicolás E, Bianco, Juan B, De Sanctis
Rok vydání:	2009
Předmět:	Adult Male Transcription Genetic Reverse Transcriptase Polymerase Chain Reaction Gene Expression Cholesterol LDL Blotting Northern Flow Cytometry Cholesterol Receptors LDL Leukocytes Humans Lupus Erythematosus Systemic Female Autoantibodies
Zdroj:	Autoimmunity. 42(4)
ISSN:	1607-842X
Popis:	The low-density lipoprotein receptor (LDLR) is directly involved in the metabolism of low-density lipoprotein (LDL) and its impairment causes accumulation of plasmatic LDL leading to atherosclerosis, a prevalent disease in patients with systemic lupus erythematosus (SLE). We studied LDLR transcription, expression and function in leukocytes patients with SLE and normal healthy donors (NHD). The ratio LDLR/glyceraldehyde-3-phosphate dehydrogenase (GADPH) mRNAs the expression of LDLR and the uptake of LDL-DiI were significantly lower (p0.001) in the patients with SLE. On the contrary, patients with SLE had significantly higher (p0.0001) levels of total cholesterol, LDL cholesterol and anti-oxLDL autoantibodies (AAb) as compared to NHD. No correlation between LDLR transcription, expression and function with the SLE disease activity index or with treatment was found. The decreased function of LDLR was independent of treatment. It seems dependent on the sterol regulatory binding protein and may be responsible for the increase of plasma LDL cholesterol and oxLDL AAb further increasing the risk of vascular diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ad3027768352f116ec3673081c176ba7 https://pubmed.ncbi.nlm.nih.gov/19811272 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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