| Autor: |
N N, Beskrovnova, G G, Konovalova, V E, Rudnik, V Z, Lankin, A M, Vikhert |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Arkhiv patologii. 53(9) |
| ISSN: |
0004-1955 |
| Popis: |
Intravenous administration of 7 alpha-hydroxycholesterol and cholestane-triol at the dose of 2.5 mg/kg produces, one day later, ultrastructural alteration of aortic endothelial cells such as cytoplasmic vacuolation, protruding and crateriform surface defects, subendothelial oedema with a subsequent exfoliation of endotheliocytes. The endothelial damage was more pronounced after the administration of equal doses of cholestane-triol as compared to 7 alpha-hydroxycholesterol. Ultrastructural changes 10 days after oral administration of 500 mg/kg cholesterol mixed with its auto-oxidation products were similar to those developing after cholestane-triol and 7 alpha-hydroxycholesterol. Cholesterol free of the oxidation products at the same doses did not produce alterations in the rabbit aortic endothelium. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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