CMY-1/MOX-family AmpC β-lactamases MOX-1, MOX-2 and MOX-9 were mobilized independently from three Aeromonas species

Autor:	Ebmeyer, Stefan, Kristiansson, Erik, Larsson, D G Joakim
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Open Reading Frames Bacterial Proteins Genetic Loci Multigene Family Gene Order Humans Aeromonas bacterial infections and mycoses Phylogeny beta-Lactamases Original Research
Zdroj:	Journal of Antimicrobial Chemotherapy
ISSN:	1460-2091 0305-7453
Popis:	Objectives To investigate the origin of CMY-1/MOX-family β-lactamases. Methods Publicly available genome assemblies were screened for CMY-1/MOX genes. The loci of CMY-1/MOX genes were compared with respect to synteny and nucleotide identity, and subjected to phylogenetic analysis. Results The chromosomal ampC genes of several Aeromonas species were highly similar to known mobile CMY-1/MOX variants. Annotation and sequence comparison revealed nucleotide identities >98% and conserved syntenies between MOX-1-, MOX-2- and MOX-9-associated mobile sequences and the chromosomal Aeromonas sanarellii, Aeromonas caviae and Aeromonas media ampC loci. Furthermore, the phylogenetic analysis showed that MOX-1, MOX-2 and MOX-9 formed three distinct monophyletic groups with the chromosomal ampC genes of A. sanarellii, A. caviae and A. media, respectively. Conclusions Our findings show that three CMY-1/MOX-family β-lactamases were mobilized independently from three Aeromonas species and hence shine new light on the evolution and emergence of mobile antibiotic resistance genes.
Databáze:	OpenAIRE
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