[Neoadjuvant endocrine therapy with anastrozole significantly downstaged an elderly breast cancer woman with locally-advanced breast cancer which became operable]

Autor:	Yoshiaki, Rai, Mitsutake, Ando, Yoshiaki, Sagara, Tetsuya, Takahama, Yoshito, Matsuyama, Yasuyo, Ooi, Yoshiatsu, Sagara
Rok vydání:	2005
Předmět:	Sternum Antineoplastic Agents Hormonal Carcinoma Ductal Breast Bone Neoplasms Breast Neoplasms Anastrozole Triazoles Combined Modality Therapy Neoadjuvant Therapy Postmenopause Lymphatic Metastasis Nitriles Preoperative Care Humans Lymph Node Excision Female Mastectomy Aged
Zdroj:	Gan to kagaku ryoho. Cancerchemotherapy. 32(9)
ISSN:	0385-0684
Popis:	A 73-year-old postmenopausal woman had a 13 cm-sized huge tumor in her left breast with an extensive purple skin color change. She had sternal destruction, axillary and supraclavicular lymph node metastases (T4bN3M1, Stage IV). Core needle biopsy showed invasive ductal carcinoma with positive hormone receptor (ER+++, PgR+++). She was treated with 1 mg per day of anastrozole. The tumor decreased in size gradually and became operable after 7.5 months of the anastrozole monotherapy. She underwent mastectomy and axillary node clearance. The resected specimen showed a 3.5 cm sized tumor with significant fibrosis and scanty viable tumor cells. We concluded that neoadjuvant therapy with anastrozole is a good choice for receptor-positive postmenopausal breast cancer, especially for elderly or poor risk women.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ace02efc33a421104f79879df4799f67 https://pubmed.ncbi.nlm.nih.gov/16184928 Zobrazit plný text záznamu