A convergent synthesis of trisaccharides with alpha-Neu5Ac-(2 --3)-beta-D-gal-(1 --4)-beta-D-GlcNAc and alpha-Neu5Ac-(2 --3)-beta-D-gal-(1 --3)-alpha-D-GalNAc sequences

Autor:	J, Xia, J L, Alderfer, C F, Piskorz, R D, Locke, K L, Matta
Rok vydání:	2000
Předmět:	Magnetic Resonance Spectroscopy Carbohydrate Sequence Molecular Sequence Data Trisaccharides N-Acetylneuraminic Acid
Zdroj:	Carbohydrate research. 328(2)
ISSN:	0008-6215
Popis:	The syntheses of three trisaccharides: alpha-Neu5Ac-(2 --3)-beta-D-Gal-(1 --4)-beta-D-GlcNAc --OMe, alpha-Neu5Ac-(2 --3)-beta-D-Gal6SO3Na-(1 --4)-beta-D-GlcNAc --OMe, and alpha-Neu5Ac-(2 --3)-beta-D-Gal-(1 --3)-alpha-D-GalNAc --OBn were accomplished by using either methyl (phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio-beta-D-glycero-D-g alacto-2-nonulopyranoside)onate or methyl (phenyl N-acetyl-5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio-beta-D-gl ycero-D-galacto-2-nonulopyranoside)onate as the sialyl donor. The N,N-diacetylamino sialyl donor appears to be more reactive than its parent acetamido sugar when allowed to react with an disaccharide acceptor under the same glycosylation conditions. The trisaccharides, as well as the intermediate products, were fully characterized by 2D DQF 1H-1H COSY and 2D ROESY spectroscopy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::accdce4ee918cc3926f16d9d882336af https://pubmed.ncbi.nlm.nih.gov/11028783 Zobrazit plný text záznamu Full Text from ScienceDirect