| Autor: |
H L, Glansbeek, P M, van der Kraan, E L, Vitters, W B, van den Berg |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Agents and actions. Supplements. 39 |
| ISSN: |
0379-0363 |
| Popis: |
TGF-beta inhibits the proteoglycan synthesis of freshly isolated articular chondrocytes while TGF-beta stimulates the proteoglycan synthesis of articular chondrocytes cultured for 14 days. To investigate if this differential effect was the result of differences in TGF-beta receptor expression this parameter was studied by affinity labeling in combination with SDS-PAGE. Using this method we demonstrated a difference in size of the TGF-beta type II receptor between freshly isolated and cultured chondrocytes. This difference might explain the differential effect of TGF-beta on the proteoglycan synthesis of chondrocytes cultured for 1 or 14 days. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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