Clinical and prognostic significance of C-reactive protein to albumin ratio in hospitalized coronavirus disease 2019 (COVID-19) patients

Autor: Lucijanić, Marko, Stojić, Josip, Atić, Armin, Čikara, Tomislav, Osmani, Besa, Barišić-Jaman, Mislav, Andrilović, Ana, Bistrović, Petra, Zrilić Vrkljan, Anamarija, Lagančić, Marko, Milošević, Marko, Vukoja, Ivan, Đerek, Lovorka, Lucijanić, Tomo, Piskač Živković, Nevenka
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Wiener Klinische Wochenschrift
ISSN: 1613-7671
0043-5325
Popis: C‑reactive protein (CRP) and albumin are inflammation sensitive parameters that are regulated by interleukin‑6 inflammatory pathways. The CRP to albumin ratio (CAR) integrates these two into a potent clinical parameter whose clinical and prognostic association in the context of coronavirus disease 2019 (COVID-19) have not been well defined. We aimed to investigate the clinical and prognostic significance of CAR in the context of COVID-19 infection. We retrospectively analyzed 2309 consecutive COVID-19 patients hospitalized at a tertiary level hospital in the period from March 2020 to March 2021 who had baseline data for a CAR assessment. Findings were validated in an independent cohort of 1155 patients hospitalized from March 2021 to June 2021. The majority of patients (85.8%) had severe or critical COVID-19 on admission. Median CRP, albumin and CAR levels were 91 mg/L, 32 g/L and 2.92, respectively. Higher CAR was associated with a tendency for respiratory deterioration during hospitalization, increased requirement of high-flow oxygen treatment and mechanical ventilation, higher occurrence of bacteriemia, higher occurrence of deep venous thrombosis, lower occurrence of myocardial infarction, higher 30-day mortality and higher postdischarge mortality rates. We defined and validated four CAR prognostic categories (
Databáze: OpenAIRE
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