Antiphospholipid syndrome in renal transplantation

Autor:	Thomas D, Barbour, Amy, Crosthwaite, Kevin, Chow, Moira J, Finlay, Nathan, Better, Peter D, Hughes, Solomon J, Cohney
Rok vydání:	2014
Předmět:	Adult Male Plasma Exchange Thrombotic Microangiopathies Biopsy Anticoagulants Antiphospholipid Syndrome Kidney Transplantation Lupus Nephritis Diagnosis Differential Treatment Outcome Predictive Value of Tests Humans Kidney Failure Chronic
Zdroj:	Nephrology (Carlton, Vic.). 19(4)
ISSN:	1440-1797
Popis:	Antiphospholipid syndrome (APS) may occur in isolation or in association with systemic lupus erythematosus (SLE), with the potential to cause renal failure via several distinct pathologies. Renal transplantation in the presence of APS carries a risk of early graft loss from arterial or venous thrombosis, or thrombotic microangiopathy (TMA). Whilst perioperative anticoagulation reduces the risk of large vessel thrombosis, it may result in significant haemorrhage, and its efficacy in preventing post-transplant TMA is uncertain. Here, we report a patient with end-stage kidney disease (ESKD) due to lupus nephritis and APS, in whom allograft TMA developed soon after transplantation despite partial anticoagulation. TMA resolved with plasma exchange-based therapy albeit with some irreversible graft damage and renal impairment. We discuss the differential diagnosis of post-transplant TMA, and current treatment options.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ac6f8b9b53ffadf7f0e11af68a6a2e13 https://pubmed.ncbi.nlm.nih.gov/24548061 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.