| Autor: |
A C, Nsonwu-Anyanwu, A, Usoro, E B, Etuk, R C, Chukwuanukwu, C A, O Usoro |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Nigerian journal of clinical practice. 24(2) |
| ISSN: |
1119-3077 |
| Popis: |
Reproductive hormones and reactive oxygen species produced by either hormonal or aerobic metabolism have been implicated in carcinogenesis of the breast and disease progression. Perturbations in the homeostasis of female reproductive hormones and oxidative stress indices in breast cancer (BCa) could be used for monitoring disease prognosis.The aim of this study was to assess levels of some biomarkers of oxidative stress and female reproductive hormones in postmenopausal women with BCa at different stages.Reduced glutathione (GSH), total antioxidant capacity (TAC), total plasma peroxides (TPP), nitric oxide (NO), malondialdehyde (MDA), estradiol (EPost-menopausal women with BCa had significantly higher BMI (26.60 ± 5.17 vs 22.73 ± 1.21 kg/mPostmenopausal women with BCa at different stages have increased estradiol, antioxidants, lipid peroxidation, and oxidative stress index suggesting that these indices may be useful for clinical assessment and monitoring progression of breast cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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