Pharmacokinetics of ethanol in mice with different alcohol motivation

Autor:	N Y, Golovenko, M S, Zhuk, V G, Zin'kovskii, O V, Zhuk, M V, Kopanitsa
Rok vydání:	2001
Předmět:	Mice Inbred C57BL Kinetics Mice Time Factors Alcohol Drinking Dose-Response Relationship Drug Ethanol Area Under Curve Mice Inbred CBA Animals Brain Central Nervous System Depressants
Zdroj:	Bulletin of experimental biology and medicine. 132(3)
ISSN:	0007-4888
Popis:	We studied the pharmacokinetics of (14)C-ethanol administered in various doses and via different routes to CBA, C57Bl/6, and (CBAxC57Bl/6)F1 mice. Kinetic scheme of ethanol distribution included its elimination by enzymatic (80-90% C(0)) and exponential (10-20% C(0)) mechanisms. Ethanol pharmacokinetics did not depend on the administration route and mouse strain. The kinetic scheme of ethanol distribution in mice was characterized by a dose-dependent linear increase in alcohol concentration in the plasma and brain and nonlinear (parabolic) increase in the area under its pharmacokinetic curve in the test tissue.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ac6992bcc98e7a3a26a87c2a34117ba8 https://pubmed.ncbi.nlm.nih.gov/11740576 Zobrazit plný text záznamu Full text from SpringerLink