Exercise with weight loss improves adipose tissue and skeletal muscle markers of fatty acid metabolism in postmenopausal women
| Autor: | Ortmeyer, Heidi K., Goldberg, Andrew P., Ryan, Alice S. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
endocrine system diseases
3-Hydroxyacyl-CoA Dehydrogenase lipoprotein lipase Citrate (si)-Synthase Article White People acyl-CoA synthase Surveys and Questionnaires Coenzyme A Ligases Weight Loss Humans Insulin Obesity Muscle Skeletal Exercise Aged Carnitine O-Palmitoyltransferase nutritional and metabolic diseases Middle Aged Overweight Lipid Metabolism carnitine palmitoyltransferase Black or African American Postmenopause β-hydroxacyl-CoA dehydrogenase lipids (amino acids peptides and proteins) Female Insulin Resistance citrate synthase Biomarkers |
| Zdroj: | Obesity (Silver Spring, Md.) |
| ISSN: | 1930-739X 1930-7381 |
| Popis: | Objective The effects of six-months weight loss (WL) versus aerobic exercise training (AEX)+WL on fat and skeletal muscle markers of fatty acid metabolism were determined in normal (NGT) and impaired (IGT) glucose tolerant African-American and Caucasian postmenopausal women with overweight/obesity. Methods Fat (gluteal and abdominal) lipoprotein lipase (LPL), and skeletal muscle LPL, acyl-CoA synthase (ACS), β-hydroxacyl-CoA dehydrogenase, carnitine palmitoyltransferase (CPT-1), and citrate synthase (CS) activities were measured at baseline (n=104) and before and after WL (n=34) and AEX+WL (n=37). Results After controlling for age and race, muscle LPL and CPT-1 were lower in IGT, and the ratios of fat/muscle LPL activity were higher in IGT compared to NGT. Muscle LPL was related to insulin sensitivity (M), and inversely related to G120, fasting insulin, and HOMA-IR. AEX+WL decreased abdominal fat LPL and increased muscle LPL, ACS, and CS. The ratios of fat/muscle LPL decreased after AEX+WL. The change in VO2max was related to the changes in LPL, ACS, and CS and inversely related to the changes in fat/muscle LPL activity ratios. Conclusions Six-month AEX+WL, and not WL alone, is capable of enhancing skeletal muscle fatty acid metabolism in postmenopausal African-American and Caucasian women with NGT, IGT, and overweight/obesity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text