Acetamide Derivatives of Chromen-2-ones as Potent Cholinesterase Inhibitors

Autor:	Suchita, Prasad, Bipul, Kumar, Shiv, Kumar, Karam, Chand, Shashank S, Kamble, Hemant K, Gautam, Sunil K, Sharma
Rok vydání:	2017
Předmět:	Erythrocytes Hemolysis Inhibitory Concentration 50 Neuroblastoma Piperidines Alzheimer Disease Blood-Brain Barrier Chromones Butyrylcholinesterase Electrophorus Indans Acetylcholinesterase Animals Humans Donepezil Cholinesterase Inhibitors
Zdroj:	Archiv der Pharmazie. 350(8)
ISSN:	1521-4184
Popis:	Alzheimer's disease (AD), a neurodegenerative disorder, is a serious medical issue worldwide with drastic social consequences. Inhibition of cholinesterase is one of the rational and effective approaches to retard the symptoms of AD and, hence, consistent efforts are being made to develop efficient anti-cholinesterase agents. In pursuit of this, a series of 19 acetamide derivatives of chromen-2-ones were synthesized and evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory potential. All the synthesized compounds exhibited significant anti-AChE and anti-BChE activity, with IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ac5a7c1b604163b36a1a2f06c297cf49 https://pubmed.ncbi.nlm.nih.gov/28699213 Zobrazit plný text záznamu Plný text