| Autor: |
Amr Ahmed, Gabr, Hyun Jik, Lee, Xaykham, Onphachanh, Young Hyun, Jung, Jun Sung, Kim, Chang Woo, Chae, Ho Jae, Han |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Biochimica et biophysica acta. Molecular basis of disease. 1863(11) |
| ISSN: |
0925-4439 |
| Popis: |
Ethanol abuse aggravates dementia-associated cognitive defects through the progression of Alzheimer's disease (AD) pathophysiology. Beta-site APP-cleaving enzyme 1 (BACE1) has been considered as a key regulator of AD pathogenesis by controlling amyloid beta peptide (Aβ) accumulation. In addition, previous studies reported that endoplasmic reticulum (ER) stress and neuroinflammation have been proposed in ethanol-induced neurodegeneration. Thus, we investigated the role of ER stress and PGE |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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