Renal tissue oxygenation after caffeine administration in preterm neonates

Autor: Matthew W, Harer, Amy C, Rothwell, Luke J, Richard, Claudette O, Adegboro, Ryan M, McAdams
Rok vydání: 2021
Předmět:
Zdroj: Pediatric research. 90(6)
ISSN: 1530-0447
Popis: Caffeine has been associated with reduced rates of acute kidney injury (AKI) in preterm neonates. The effect of caffeine on preterm neonatal renal regional saturation of oxygen (RrSORrSOOf 35 eligible neonates, 31 (median gestational age 28.4 weeks) received 156 caffeine doses (median 8 mg/kg). Analysis of combined doses showed no significant changes in RrSOMaintenance caffeine dosing increased RrSOCaffeine administration is associated with increased renal tissue oxygenation in preterm neonates with low baseline values under 40%. The most significant renal tissue oxygenation changes occur in the first 3 h after IV caffeine administration. With recent studies suggesting low RrSO
Databáze: OpenAIRE