| Autor: |
Borna, Relja, Maika, Szermutzky, Dirk, Henrich, Marcus, Maier, Jacco-Juri, de Haan, Tim, Lubbers, Wim A, Buurman, Ingo, Marzi |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 17(7) |
| ISSN: |
1553-2712 |
| Popis: |
Fatty acid-binding proteins (FABPs) have relatively high tissue concentrations and low plasma concentrations and are released into the circulation following organ injury. We explored the utility of intestinal-(I)-FABP and liver-(L)-FABP for the diagnosis of abdominal injury in patients with multiple trauma.This prospective study included 102 trauma patients and 30 healthy volunteers. Plasma I-FABP and L-FABP levels were measured in the emergency department (ED) by enzyme-linked immunosorbent assay (ELISA). Forty-one patients suffered from serious or severe abdominal trauma (Abbreviated Injury Score [AIS] code "ai" for abdominal injury, AISaior = 3) and nine were moderately abdominally injured (AISai3). Fifty-two had no abdominal injury.Median I-FABP and L-FABP levels in the AISaior = 3 group (516 pg/mL and 135 ng/mL, respectively) were significantly higher compared to the AISai3 group (154 pg/mL and 13 ng/mL, respectively) or those without abdominal injury (207 pg/mL and 21 ng/mL, respectively) or normal controls (108 pg/mL and 13 ng/mL, respectively). The cutoff to distinguish the aior = 3 is 359 pg/mL for I-FABP and 54 ng/mL for L-FABP, with 93% specificity and 75% sensitivity for I-FABP and 93% and 82% for L-FABP, respectively.High I-FABP and L-FABP levels correlate with relevant severity of abdominal tissue damage in patients with multiple trauma. I-FABP and L-FABP could be useful as markers for the early detection of significant abdominal injury in acute multiple trauma and identify patients who require rapid intervention. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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