| Autor: |
Shumeng, Lin, Jing, Wen, Xiao, Xu, Jiamin, Shi, Wen, Zhang, Tiansheng, Zheng, Yaqin, Hou, Yanfei, Zhang, Ziye, Li, Kai, Wang, Jing, Jin, Liduo, Yue, Baigenzhin, Abay, Ming, Li, Qingxi, Yue, Lihong, Fan |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
The American journal of Chinese medicine. 50(5) |
| ISSN: |
1793-6853 |
| Popis: |
Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death worldwide. Amygdalin, a natural compound commonly distributed in plants of the Rosaceae species, owns anticancer activity, less side effects, wide source, and relatively low price. Although the apoptosis is a central process activated by amygdalin in cancer cells, the underlying molecular mechanisms through which amygdalin induces the apoptosis of lung cancer cells remain poorly understood. In this research work, amygdalin could suppress the proliferation of lung cancer A549 and PC9 cells by CCK8 assay. Amygdalin significantly promoted the apoptosis of lung cancer A549 and PC9 cells stained with Annexin V-FITC/PI by flow cytometry assay. Furthermore, amygdalin dose-dependently decreased the mitochondrial membrane potential (MMP) with JC-1 dye by flow cytometry. To investigate the underlying molecular mechanisms through which amygdalin induced mitochondria-mediated apoptosis of cancer cells, the differentially-expressed genes with a fold change2.0 and |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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