The effect of Craviten, a new antiarrhythmic drug, its 2R, 2'R isomer, quinidine and procaine amide on human platelet aggregation

Autor:	T, Kedryna, M, Gumińska, M, Eckstein
Rok vydání:	1980
Předmět:	Adenosine Diphosphate Adenosine Triphosphate Platelet Aggregation Humans Nitracrine Stereoisomerism Procainamide Ethylenediamines Anti-Arrhythmia Agents Quinidine
Zdroj:	Polish journal of pharmacology and pharmacy. 32(6)
ISSN:	0301-0244
Popis:	Among the optical isomers of N, N'-dimethyl-N, N'-bis[1-(3', 4', 5-trimethoxybenzoyloxy)-butyl-2]-ethylenediamine dihydrochloride only the isomer with the (2S, 2'S) configuration (Craviten) in a concentration of 0.2 microgram/ml inhibits the ADP-induced aggregation of human platelets. The (2R, 2'R) isomer and quinidine exert a similar effect but only in a concentration ten times higher. Procaine amide (2 micrograms/ml) has an opposite effect, stimulating human platelet aggregation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ab8565428b267ec9d856f940e6869985 https://pubmed.ncbi.nlm.nih.gov/7243684 Zobrazit plný text záznamu