| Autor: |
Bilé Cyrille Hervé, Ehounoud, Celia Scherelle, Boumbanda Koyo, Landry, Doua Bongue, Sébastien, Cortaredona, Adèle, N'Douba Kakou, Djanwai Berenger, Konan, Yao, Kouassi Patrick, Nadia, Amanzougaghene, Jean-David, N'Guessan, Bernard, Davoust, Didier, Raoult, Oleg, Mediannikov, Florence, Fenollar |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Travel medicine and infectious disease. 43 |
| ISSN: |
1873-0442 |
| Popis: |
The aetiologies of fever are poorly understood in sub-Saharan Africa. We aimed to assess the burden of malaria and bacteria in Côte d'Ivoire.Blood samples from 438 febrile and 346 afebrile people were screened using molecular tools.Plasmodium falciparum was the most common microorganism associated with fever (46.8% in febrile, 23.4% in afebrile people; p 0.001). Bacteraemia was detected in 21.7% of febrile people and 12.7% of afebrile people (p = 0.001). Streptococcus pneumoniae was the main cause of bacteraemia (7.1% of febrile and 0.6% of afebrile individuals; p 0.001). Non-typhoidal Salmonella spp. was detected in 4.5% of febrile people and 1.2% of afebrile individuals (p 0.001). Salmonella enterica Typhi and S. enterica Paratyphi were only detected in febrile subjects (1.4% and 2.1%), as well as Tropheryma whipplei (0.9%), Streptococcus pyogenes (0.7%), and Plasmodium ovale (4.6%). The prevalence in febrile and afebrile people was similar for Staphylococcus aureus (3.6-4.9%), Rickettsia felis (5.5-6.4%), Mansonella perstans (3.0-3.2%), and Plasmodium malariae (1.6-2.3%). Comorbidities were higher in febrile than in afebrile subjects (10.3% versus 5.5%; p = 0.01); 82% involving P. falciparum. All patients co-infected with P. falciparum and S. pneumoniae were febrile whereas 30% of those infected by P. falciparum alone were not (p = 0.02). Among febrile participants, 30.4% with malaria and 54.7% with bacteraemia had received neither antimalarial nor antibiotic therapy.Identification of etiologies of acute febrile diseases in sub-Saharan Africa proposes keys to successful treatment and prevention of infectious diseases. Vaccination campaigns may decrease the morbidity of mono- and co-infections by preventable microorganisms. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect