[Neuroimaging of the dopamine transporter in Parkinsons disease: first study using [99mTc]-TRODAT-1 and SPECT in Brazil]
| Autor: | Ming Chi, Shih, Edson, Amaro, Henrique Ballalai, Ferraz, Marcelo Queiroz, Hoexter, Fabricio Oliveira, Goulart, Jairo, Wagner, Li Fu, Lin, Ying Kai, Fu, Jair Jesus, Mari, Acioly Luiz Tavares, de Lacerda, Sergio, Tufik, Rodrigo Affonseca, Bressan |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Tomography Emission-Computed Single-Photon Dopamine Plasma Membrane Transport Proteins Reproducibility of Results Parkinson Disease Organotechnetium Compounds Middle Aged Sensitivity and Specificity Severity of Illness Index Case-Control Studies Humans Female Radiopharmaceuticals Aged Tropanes |
| Zdroj: | Arquivos de neuro-psiquiatria. 64(3A) |
| ISSN: | 0004-282X |
| Popis: | Dopamine transporter (DAT) neuroimaging radiotracers were developed to estimate dopamine neuronal loss in vivo in Parkinsons disease (PD).To evaluate DAT density in vivo using [99mTc]-TRODAT-1 and single photon computerized tomography (SPECT) in a population of Brazilian PD.Fifteen PD patients and 15 matched healthy controls scanned with [99mTc]-TRODAT-1 (INER-Taiwan) and SPECT. Estimates of striatum DAT density were calculated using binding potential (BP). Patients were assessed with PD scales.PD patients had significantly lower striatal DAT-BP (mean+/-SD) (0.38+/-0.12) compared to controls (BP=0.84+/-0.16; p0.01). A 100% sensitivity and 100% specificity was obtained to discriminate PD cases from controls. Negative correlations between striatal DAT-BP and PD severity (rho=-0.7, p0.001) and motor scales (rho=-0.80, p0.001) were found.[99mTc]TRODAT-1 SPECTs scanning was able to discriminate PD patients from controls. The technique is a powerful instrument to measure DAT density that can be used in clinical and research settings in Brazil. |
| Databáze: | OpenAIRE |
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