Translocation t(1;22) mimicking t(1;19) in a child with acute lymphoblastic leukemia as revealed by chromosome painting
| Autor: | H, Rieder, U, Kolbus, U, Koop, W D, Ludwig, B, Stollmann-Gibbels, C, Fonatsch |
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| Rok vydání: | 1993 |
| Předmět: |
Chromosome Aberrations
Gene Rearrangement Male Chromosomes Human Pair 21 Chromosomes Human Pair 11 Chromosomes Human Pair 22 Precursor Cell Lymphoblastic Leukemia-Lymphoma Translocation Genetic Chromosomes Human Pair 1 Karyotyping Humans Child Chromosomes Human Pair 18 DNA Probes Chromosomes Human Pair 19 In Situ Hybridization |
| Zdroj: | Leukemia. 7(10) |
| ISSN: | 0887-6924 |
| Popis: | The karyotype of a boy with acute lymphoblastic leukemia (ALL) presenting with numerical and structural chromosome aberrations as determined by Giemsa-banding was further investigated using chromosome painting (CP). A translocation t(11;18)(q23;q21) was verified by this approach, and gain of chromosome 21 material due to a structural rearrangement was detected. Moreover, an unbalanced translocation of the long arm of chromosome 1, resembling the well known translocation t(1;19), was demonstrated to involve chromosome 22 instead of chromosome 19. Immunophenotyping of the leukemic blasts led to the diagnosis common ALL (CD19+, CD10+, clg-). Our case indicates that in ALL a translocation t(1;19) may be mimicked by other chromosomal rearrangements, and that CP may efficiently complement conventional cytogenetics in the exact characterization of the involved chromosomes. |
| Databáze: | OpenAIRE |
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