The factor V G1691A mutation is a risk for porencephaly: A case-control study

Autor:	Otfried M, Debus, Andrea, Kosch, Ronald, Sträter, Rainer, Rossi, Ulrike, Nowak-Göttl
Rok vydání:	2004
Předmět:	Male Risk Brain Diseases Alanine Chi-Square Distribution Genotype Glycine Factor V Infant Risk Factors Case-Control Studies Multivariate Analysis Mutation Humans Female Genetic Predisposition to Disease Prothrombin Child Retrospective Studies
Zdroj:	Annals of neurology. 56(2)
ISSN:	0364-5134
Popis:	This study was initiated to investigate prothrombotic risk factors in children with porencephaly. 76 porencephalic and 76 healthy infants were investigated for factor V (FV) G1691A mutation, factor II G20210A variant, methylenetetrahydrofolate reductase (MTHFR) C677T genotype, lipoprotein (a), protein C, protein S, and antithrombin. Only the FV mutation (p = 0.005) and combinations of two or three different risk factors (p = 0.003) were significantly associated with porencephaly. These data give evidence that the FV G1691A mutation and a combination of prothromboic factors play a major role in the development of childhood porencephaly.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ab39d533b6b039212a52fafc132aea94 https://pubmed.ncbi.nlm.nih.gov/15293282 Zobrazit plný text záznamu Plný text