| Autor: |
Ming-Jia, Liu, Li-Hong, Chen, Kai-Feng, Hu, Xiao-Long, Yang, Jing-Ying, Dong, Ji, Liu |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 47(4) |
| ISSN: |
1672-173X |
| Popis: |
To study the regulation to colon cancer cellular biological properties through miR-18a targeting ataxia-telangiectasia mutated gene (A target of miR-18a was predicted by using bioinformatics tools. The miR-18a mimics and inhibitors were designed and synthesized. The expression of endogenous miR-18a in colon cancer cell line HCT116 was up-regulated or down-regulated by transfection. The effect of overexpression of miR-18a on cellular proliferation, invasion and migration via regulation ofmiR-18a inhibited the proliferation and migration of colon cance cell HCT116 through negative regulation of ATM expression. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
