| Autor: |
B, Pojanagaroon, S, Boonmar, K, Chatiyanonda, S, Nimmannitya, Y, Thanasophon, S, Suksangium, V, Sirivasin, C, Chantrachaya, K, Mizuno |
| Rok vydání: |
1988 |
| Předmět: |
|
| Zdroj: |
The Southeast Asian journal of tropical medicine and public health. 19(4) |
| ISSN: |
0125-1562 |
| Popis: |
Two hundred and four newborn infants of HBsAg/HBeAg carrier mothers were randomly assigned into three groups. Group A (69 infants) received full-dose HB vaccine, group B (70 infants) received half-dose HB vaccine at birth, 1 month, 3 months and group C (65 infants) were untreated control group. After twelve months follow-up the cumulative incidence of HBs antigenemia was 17.2%, 30% in group A, B respectively as compared with 78.4% in group C (p less than 0.001). The protective efficacy rates (PER) of group A and B were 78.1% and 61.7% respectively (p less than 0.05). The vaccine was also effective in preventing persistent HBsAg carriers (HBsAg positive for at least 6 months). The PER of group A and B were at least 74.9% and 49.2% respectively (p less than 0.001) at 1 year follow-up. From the practical point of view and economic reasons administration of full-dose HB vaccine give better protection to high risk infants. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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