| Autor: |
Gabriele, Coraggio, Shan, Husheng, Gokoulakrichenane, Loganadane, Sahar, Ghith, Noémie, Grellier, Marie Laure, Hervé, Nhu Hanh, To, Laurianne, Colson Durand, Annie, Jouhaud, Maryse, Fayolle Campana, Maya, Nourieh, Dimitri, Vordos, Yazid, Belkacemi |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 25(4) |
| ISSN: |
2241-6293 |
| Popis: |
The optimal schedule for palliative external beam radiotherapy (EBRT) in patients with bladder tumors with hematuria unfit for surgery remains undefined. This study aimed to assess the clinical hemostatic efficacy and safety of two EBRT hypofractionated schedules.From February 2008 to October 2017, 31 patients were referred to our department for palliative hemostatic bladder irradiation. EBRT consisted of two schedules: "continuous" treatment (CRT) was delivered following consecutive 3-10 weekdays (3-6Gy/fraction (fr), to a total dose of 18-30Gy) (n=14); the "discontinuous" schedule (DRT) consisted of 23Gy in 4fr (6.5Gy/fr on days 1 and 3, followed by 5Gy/fr on days 15 and 17; n=12). The primary endpoint was the rate of hemostatic control (HC) at the end of the radiation course. Other endpoints included mid-term HC, toxicities and overall survival. Comparative analyses were performed by exact Fisher test with a cut-off of 0.05 for statistical significance.The rate of HC at the end of EBRT was 92% (n=24) with no differences between CRT and DRT (100% vs 86%; p=0.48). The median follow-up was 6 months, HC was achieved in 15/26 (58%) patients at the last follow-up, without meaningful differences between CRT and DRT (50% vs 67%; p=0.45). Three and two patients developed acute grade ≤2 diarrhea in CRT and DRT groups, respectively.Our study suggests that both hypofractionated "continuous" and "discontinuous" EBRT are well tolerated and represent acceptable schedules for patients with limited life expectancy. DRT schedule could be preferred for departments' organization to increase the slots for the treatment of other referred patients for radiotherapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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