Association of Mortality with Ocular Diseases and Visual Impairment in the Age-Related Eye Disease Study 2 (AREDS2): AREDS2 Report Number 13
| Autor: | Papudesu, Chandana, Clemons, Traci E., Agrón, Elvira, Chew, Emily Y. |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
genetic structures Visual Acuity Angiogenesis Inhibitors Cataract Extraction Slit Lamp Microscopy Article Cohort Studies Macular Degeneration Double-Blind Method Zeaxanthins Cause of Death Fatty Acids Omega-3 Humans Aged Proportional Hazards Models Aged 80 and over Lutein Middle Aged eye diseases United States Survival Rate Dietary Supplements Female sense organs Visually Impaired Persons Follow-Up Studies |
| Popis: | OBJECTIVES: To evaluate the association of mortality with visual acuity (VA) impairment, age-related macular degeneration (AMD), and cataract surgery. DESIGN: Cohort study SUBJECTS: Participants with at least intermediate AMD enrolled in a randomized controlled clinical trial of lutein/zeaxanthin and/or omega-3 fatty acids, the Age-Related Eye Disease Study 2 (AREDS2) for treatment of AMD and cataract. METHODS: Baseline and annual eye examinations included best-corrected visual acuity (BCVA) assessments, slit lamp examinations, and stereoscopic fundus photographs that were centrally graded for development of late AMD (central geographic atrophy or neovascular AMD) or pseudophakia. Cause-specific mortality was determined based on ICD-9 or ICD-10 codes. Risk of all-cause and cause-specific mortality was assessed with Cox proportional hazards models adjusted for age, sex, AMD severity, VA, history of cataract surgery, and assigned AREDS2 study treatment. Analyses included baseline covariates: race, education, smoking status, diabetes, and cardiovascular disease. RESULTS: During follow-up (median 5 years), 368 (9%) of the 4203 AREDS2 participants died. Participants with neovascular AMD in 1 eye at baseline had a statistically significant increased risk for mortality compared to participants with no or few drusen (hazard ratio [HR] 1.56, 95% confidence interval [CI], 1.21–2.01; p-value [p] |
| Databáze: | OpenAIRE |
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