| Autor: |
Yi-Ying, Wang, Xuan, Wu, Cheng-Lin, Tang, Yi, Xu, Jian-Rong, Wang, Jin, Xu, Juan, Huang, Guo-Ping, Qiu, Hua-Jun, Sheng, Shu-Juan, Zhu |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Zhen ci yan jiu = Acupuncture research. 45(8) |
| ISSN: |
1000-0607 |
| Popis: |
To compare the effect of electroacupuncture (EA) of acupoint group for "reinforcing the kidney and regulating Governor Vessel" and acopoint group for "reinforcing the kidney and lung and regulating Governor Vessel" on lear-ning-memory ability and expression of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) proteins in the hippocampus and prefrontal cortex (PFC) in Alzheimer's disease （AD） rats, so as to explore the efficacy of the two acupoint groups and mechanisms underlying improvement of AD.Forty male SD rats were randomly divided into control, sham operation, model, "Baihui" + "Shenshu" (GV20+BL23, for "reinforcing the kidney and regulating Governor Vessel") EA and GV20+BL23+ "Feishu" (BL13, GV20+BL23+BL13, for "reinforcing the kidney and lung and regulating Governor Vessel") EA groups (Following modeling, the average escape latency of place navigation test were significantly increased (EA of both GV20+BL23 and GV20+BL23+BL13 acupoint can improve learning-memory ability of AD rats, which is associated with their effects in down-regulating the expression of IL-1β and TNF-α in the PFC and hippocampus to reduce inflammatory reaction. There were no significant differences between the two acupoint groups in the therapeutic effects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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