| Autor: |
O, Ohneda, K, Ohneda, H, Nomiyama, Z, Zheng, S A, Gold, F, Arai, T, Miyamoto, B E, Taillon, R A, McIndoe, R A, Shimkets, D A, Lewin, T, Suda, L A, Lasky |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Immunity. 12(2) |
| ISSN: |
1074-7613 |
| Popis: |
Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effect on either myeloid or B cell formation. WECHE repressed BFU-E development from either mouse fetal liver or bone marrow progenitor cells but had no effect on colony formation induced by IL-3 or IL-7. WECHE reduced HPP-CFC production from fetal liver-derived stem cells. WECHE hindered the growth of yolk sac-derived endothelial cells. WECHE was also chemotactic for bone marrow cells. Thus, WECHE is a novel chemokine that regulates hematopoietic differentiation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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