[The effect of plasmin and its complexes with alpha 2-antiplasmin and alpha 2-macroglobulin on secretion of proteinase and plasminogen inhibitors from peripheral mononuclear cells]

Autor:	S G, Zhabin, N A, Zorin, M I, Musatov
Rok vydání:	1995
Předmět:	alpha-2-Antiplasmin Hydrolysis Leukocytes Mononuclear Humans Plasminogen Protease Inhibitors alpha-Macroglobulins Fibrinolysin Antifibrinolytic Agents
Zdroj:	Voprosy meditsinskoi khimii. 41(3)
ISSN:	0042-8809
Popis:	Secretion of proteinase inhibitors alpha2-macroglobulin, alpha1-proteinase inhibitor, inter-alpha-trypsin inhibitor and plasminogen was distinctly altered in mononuclear cell from peripheric blood of volunteers if these cells were preincubated simultaneously with alpha2-macroglobulin and alpha2-antiplasmin modified by plasmin. The complex plasmin-alpha2-macroglobulin was shown to stimulate most effectively the alpha2-macroglobulin and alpha1-proteinase inhibitor secretion. Besides, plasmin-alpha2-macroglobulin complex inhibited the inter-alpha-trypsin inhibitor secretion, whereas the complex plasmin-alpha2-antiplasmin--stimulated. Both these complexes augmented the rate of plasminogen synthesis in the mononuclear cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::aaa2584e1c353dc7f560ef6af95e5592 https://pubmed.ncbi.nlm.nih.gov/8585176 Zobrazit plný text záznamu