Insulin, glibenclamide or metformin treatment for non insulin dependent diabetes: heterogenous responses of standard measures of insulin action and insulin secretion before and after differing hypoglycaemic therapy

Autor:	K, Boyd, C, Rogers, C, Boreham, W J, Andrews, D R, Hadden
Rok vydání:	1992
Předmět:	Blood Glucose Glycated Hemoglobin Radioisotope Dilution Technique C-Peptide Metabolic Clearance Rate Middle Aged Tritium Metformin Body Mass Index Diabetes Mellitus Type 2 Glycosuria Glyburide Insulin Secretion Glucose Clamp Technique Humans Insulin Insulin Resistance
Zdroj:	Diabetes research (Edinburgh, Scotland). 19(2)
ISSN:	0265-5985
Popis:	Using carefully selected relatively non-obese non insulin dependent diabetic patients, we were not able to show differences in standard measures of insulin production or insulin action between patients treated with a long acting crystalline zinc insulin, with glibenclamide, or with metformin for a six week period. All three drugs were hypoglycaemic, but a fall in basal hepatic glucose output measured by the 3H3 glucose technique was only seen in those patients who had an initial fasting plasma glucose above 12.0 mmol/l, irrespective of treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::aa75c56229c0ee601cb011bd8fa7997c https://pubmed.ncbi.nlm.nih.gov/1286541 Zobrazit plný text záznamu