Regional combined with systemic chemotherapy in unresectable biliary tract cancers: a phase II study
| Autor: | M, Cantore, G, Fiorentini, A, Mambrini, C, Rabbi, D, Zamagni, N, Carlone, A, Manni, R, Caudana, T, Torri |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Venous Thrombosis Antineoplastic Agents Adenocarcinoma Middle Aged Disease-Free Survival Biliary Tract Neoplasms Catheters Indwelling Treatment Outcome Injections Intra-Arterial Doxorubicin Chemotherapy Cancer Regional Perfusion Antineoplastic Combined Chemotherapy Protocols Humans Female Fluorouracil Cisplatin Aged |
| Zdroj: | Journal of experimentalclinical cancer research : CR. 22 |
| ISSN: | 0392-9078 |
| Popis: | Unresectable biliary tract cancers have a very poor prognosis. No good systemic chemotherapeutic regimen is available. This study aimed to evaluated the activity and toxicity of a novel approach of combined loco-regional and systemic chemotherapy. Twenty four patients with advanced or metastatic biliary tumors were treated with epiadriamycin 50 mg/m2 and cisplatin 60 mg/m2 administered bolus in proper hepatic artery on day 1, combined with systemic continuous infusion of 5-fluorouracil 200 mg/m2/day, from day 1 to day 14, every 3 weeks. The overall response rate was 8/24 (33%), including one complete response and 7 partial responses (stable disease 46%, progression 21%). The treatment was well tolerated with a minimal hematological toxicity; the major clinical problem was the deep venous thrombosis related to central venous catheter, that occurred in 5 patients (21%). Median overall survival was 14,6 months and 1-year and 2-year survival were 54% and 38% respectively. Performance status improved in 33% of patients and weight gain more than 7% was observed in 17%. This novel combined loco-regional and systemic chemotherapeutic regimen is active and safe for advanced biliary tract cancer patients. |
| Databáze: | OpenAIRE |
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