Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8
| Autor: | Claire Louse, Gordon, Lian Ni, Lee, Leo, Swadling, Claire, Hutchings, Madeleine, Zinser, Andrew John, Highton, Stefania, Capone, Antonella, Folgori, Eleanor, Barnes, Paul, Klenerman |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Genetic Vectors CX3C Chemokine Receptor 1 T cells Cytomegalovirus Mice Transgenic Hepacivirus CD8-Positive T-Lymphocytes Viral Nonstructural Proteins Article Adenoviridae memory Mice Young Adult CX3CR1 Animals Humans human memory inflation mouse Vaccines Synthetic Viral Vaccines adenovirus Middle Aged vaccination Tumor Necrosis Factor Receptor Superfamily Member 7 Mice Inbred C57BL Immunologic Memory |
| Zdroj: | Cell Reports |
| ISSN: | 2211-1247 |
| Popis: | Summary The induction and maintenance of T cell memory is critical to the success of vaccines. A recently described subset of memory CD8+ T cells defined by intermediate expression of the chemokine receptor CX3CR1 was shown to have self-renewal, proliferative, and tissue-surveillance properties relevant to vaccine-induced memory. We tracked these cells when memory is sustained at high levels: memory inflation induced by cytomegalovirus (CMV) and adenovirus-vectored vaccines. In mice, both CMV and vaccine-induced inflationary T cells showed sustained high levels of CX3R1int cells exhibiting an effector-memory phenotype, characteristic of inflationary pools, in early memory. In humans, CX3CR1int CD8+ T cells were strongly induced following adenovirus-vectored vaccination for hepatitis C virus (HCV) (ChAd3-NSmut) and during natural CMV infection and were associated with a memory phenotype similar to that in mice. These data indicate that CX3CR1int cells form an important component of the memory pool in response to persistent viruses and vaccines in both mice and humans. Graphical Abstract Highlights • CX3CR1int T cells are a large component of memory induced by CMV and adenovaccines • Inflating CX3CR1int cells exhibit an effector-memory phenotype but can proliferate • Human inflationary CX3CR1int cells induced by CMV and adenovaccines share features • CX3CR1int cells contribute to memory expansion in specific infections or vaccines Gordon et al. demonstrate that CX3CR1int peripheral memory T cells are a substantial component of memory inflation induced by persistent CMVs and adenoviral vaccination. They are characterized by sustained proliferation and an effector-memory phenotype linked to these expanded CD8+ T cell memory responses. Core phenotypic features are shared by humans and mice. |
| Databáze: | OpenAIRE |
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