| Autor: |
G M, van Dam, B W, Verbaan, T M, Therneau, E R, Dickson, M, Malinchoc, P A, Murtaugh, J R, Huizenga, C H, Gips |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Hepato-gastroenterology. 44(15) |
| ISSN: |
0172-6390 |
| Popis: |
A retrospective study of primary biliary cirrhosis (PBC) was performed to study the Original Mayo Model for predicting survival by a Dutch data-set of patients, presentation of disease progression; assessment of liver transplantation, prediction of post-transplantation survival; and the addition of two laboratory variables to the Original Mayo Model.Survival of 83 patients, 37 of whom underwent transplantation, were studied. Mean follow-up was 6.0 +/- 0.45 SEM years. Risk score at diagnosis, platelet count, and serum sodium were analyzed in a Cox model.The Original Mayo Model estimated survival for low-, medium-, and high-risk groups accurately and it also presented disease progression. Baseline Mayo risk score in a Cox model had a regression coefficient of 1.01, indicating an excellent predictor p0.0001. Platelet count was a predictor of survival (p0.002), whereas serum sodium did not (p = 0.67). A new model combined of the Original Mayo risk score and platelet count predicted survival in high-risk patients somewhat better compared to the Original Mayo Model. With both models, liver transplantation had a significant beneficial effect on survival (p0.001). The scores revealed no significant influence (p = 0.47) for overall post-transplantation survival.The Original Mayo Model remains the model of choice for patients with PBC for prognostication from 3-8 years, is a useful tool in the assessment of liver transplantation but not an indicator of post-transplantation survival. Platelet count showed to have additional prognostic value. A new model combined of platelet count and the Original Mayo risk score did predict survival in high-risk groups slightly better compared to the Original Mayo Model. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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