Identification of a novel DPB1* allele (DPB1*6901) and the occurrence of HLA haplotypes that extend to DPB1

Autor:	M D, Varney, B D, Tait
Rok vydání:	2000
Předmět:	HLA-DP Antigens DNA Complementary Base Sequence Haplotypes Sequence Homology Nucleic Acid Molecular Sequence Data Humans Alleles HLA-DP beta-Chains
Zdroj:	Tissue antigens. 55(2)
ISSN:	0001-2815
Popis:	The sequence of a novel DPB1 allele, DPB1*6901, observed in a Caucasian bone marrow donor phenotype HLA A2; Cw*0501,*1601; B*4402, *4403; DRB1*0401; *07; DQB1*02; *0301; DPB1*0401; *6901, is described. The sequence is consistent with that previously described for DPB1*0601 with the exception of codon 69. The sequence at this codon is consistent with that previously observed only in the DPB1*1101 and *1501 alleles. It is suggested that DPB1*6901 may have arisen as a result of a recombination event occurring between codons 58 and 64 between DPB1*0601 and DPB1*1101. The sequence of DPB1*1501 from codon 64 is not consistent with DPB1*6901. A linkage disequilibria analysis that examined 212 potential bone marrow recipients in which HLA-A to DQ haplotypes had been established by family studies showed linkage disequilibrium between HLA-B, DRB1 and DPB1 in some haplotypes and not others.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::aa09df8644b7485fdc3f376a6d1108b4 https://pubmed.ncbi.nlm.nih.gov/10746796 Zobrazit plný text záznamu Plný text