[Selective cytostatic and cytotoxic effects of avermectins]

Autor: V A, Driniaev, V A, Mosin, E B, Krugliak, T S, Sterlina, A V, Viktorov, V G, Tsyganova, A F, Korystova, A S, Grichenko, K I, Zenchenko, Iu M, Kokoz
Rok vydání: 2001
Předmět:
Zdroj: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 46(5)
ISSN: 0235-2990
Popis: A natural avermectin complex, aversectin C, was shown to be capable of exerting selective cytostatic effect. It killed proliferating neuroblastoma B 103 cells but was non-toxic for differentiated cells of this culture. The activity of aversectin C was related neither to activation of the GABA alpha-receptors nor to their blocking and was at a large extent due to the action of avermectin A1, a component of aversectin C.
Databáze: OpenAIRE