| Autor: |
Kuei-Man, Lin, Mei-Due, Yang, Chia-Wen, Tsai, Wen-Shin, Chang, Chieh-Lun, Hsiao, Long-Bin, Jeng, Te-Cheng, Yueh, Meng-Chih, Lee, DA-Tian, Bau |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Anticancer research. 38(4) |
| ISSN: |
1791-7530 |
| Popis: |
To evaluate the contribution of methylenetetrahydrofolate reductase (MTHFR) genotype to the risk of colorectal cancer (CRC) in Taiwan.In this hospital-based case-control study, the role of MTHFR C677T (rs1801133) and A1298C (rs1801131) genotypes in determining CRC risk were investigated among 362 patients with CRC and an equal number of age- and gender-matched healthy individuals.The percentages of CC, CT and TT genotypes for MTHFR rs1801133 were 64.1%, 29.8% and 6.1% in the CRC group and 51.1%, 37.0% and 11.9% in the control group, respectively (p for trend=0.0006). Analysis of the allelic frequency distribution showed that the variant T allele of MTHFR rs1801133 conferred a lower CRC susceptibility than did the wild-type C allele (odds ratio(OR)=0.66, 95% confidence interval(CI)=0.52-0.84, p=4.32×10MTHFR rs1801133 T allele serves as a predictive marker for CRC risk and future studies with larger samples and functional evaluation are warranted to validate the current findings. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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