Peptidergic (VIP) nerves in normal human pancreas and in pancreatitis: an immunohistochemical study

Autor: L, Marongiu, M T, Perra, A D, Pinna, F, Sirigu, P, Sirigu
Rok vydání: 1993
Předmět:
Zdroj: Histology and histopathology. 8(1)
ISSN: 0213-3911
Popis: Vasoactive intestinal polypeptide was demonstrated in the nerves of the human normal pancreas and in pancreatitis by light microscope immunohistochemical technique. In specimens of normal pancreas, vasoactive intestinal polypeptide-immunoreactive neuronal cells were present in the autonomic ganglia. These ganglia were found to receive an abundant supply of vasoactive intestinal polypeptide-positive fibre plexuses. Immunoreactive nerve fibres were seen to run in the stroma, in association with secretory acini, ducts and blood vessels. Vasoactive intestinal polypeptide-positive fibres were also seen close to the Langerhans' islets, but no vasoactive intestinal polypeptide-like immunoreactivity was observed in the endocrine cells. In specimens from patients affected by pancreatitis, even in lesioned regions, immunoreactive elements were extremely scarce.
Databáze: OpenAIRE