August rats are more resistant to arrhythmogenic effect of myocardial ischemia and reperfusion than Wistar rats

Autor:	L M, Belkina, T N, Kirillina, M G, Pshennikova, Yu V, Arkhipenko
Rok vydání:	2002
Předmět:	Male Species Specificity Myocardial Ischemia Animals Arrhythmias Cardiac Myocardial Reperfusion Injury Rats Inbred Strains Enzyme Inhibitors Nitric Oxide Synthase Rats Wistar Nitric Oxide Nitroarginine Rats
Zdroj:	Bulletin of experimental biology and medicine. 133(6)
ISSN:	0007-4888
Popis:	As differentiated from Wistar rats, myocardial ischemia and reperfusion produce no ventricular fibrillation in August rats. Pretreatment with nitric oxide synthase inhibitor Nw-nitro-L-arginine increased mortality rate in August rats with acute myocardial infarction from 20 to 40%. Under these conditions mortality rate in Wistar rats increased from 50 to 71%. Interstrain differences in the resistance of these animals to the arrhythmogenic effect of ischemia are probably associated with higher activity of the nitric oxide system in August rats compared to Wistar rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a9cf4657a4564102d6d065d57681f791 https://pubmed.ncbi.nlm.nih.gov/12447459 Zobrazit plný text záznamu Full text from SpringerLink