Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man

Autor:	N C, Sambol, L G, Brookes, J, Chiang, A M, Goodman, E T, Lin, C Y, Liu, L Z, Benet
Rok vydání:	1996
Předmět:	Adult Male Analysis of Variance Dose-Response Relationship Drug Intestinal Absorption Humans Hypoglycemic Agents Energy Intake Metformin
Zdroj:	British journal of clinical pharmacology. 42(4)
ISSN:	0306-5251
Popis:	The pharmacokinetics of four single-dose treatments of the metformin administered orally (as the HCl salt) were compared in 24 healthy subjects: 500 mg and 850 mg tablets and 850 mg solution fasting and 850 mg tablet with food. Solution and tablet formulations are bioequivalent. Bioavailability of a 500 mg tablet is 14% greater than that of an 850 mg tablet. Compared with the fasting state, bioavailability is 24% lower, and the peak concentration delayed about 37 min when an 850 mg tablet is administered with food.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a9c3abbef60052d59ed0d23c4b4913c0 https://pubmed.ncbi.nlm.nih.gov/8904626 Zobrazit plný text záznamu Plný text