Autor: |
N C, Sambol, L G, Brookes, J, Chiang, A M, Goodman, E T, Lin, C Y, Liu, L Z, Benet |
Rok vydání: |
1996 |
Předmět: |
|
Zdroj: |
British journal of clinical pharmacology. 42(4) |
ISSN: |
0306-5251 |
Popis: |
The pharmacokinetics of four single-dose treatments of the metformin administered orally (as the HCl salt) were compared in 24 healthy subjects: 500 mg and 850 mg tablets and 850 mg solution fasting and 850 mg tablet with food. Solution and tablet formulations are bioequivalent. Bioavailability of a 500 mg tablet is 14% greater than that of an 850 mg tablet. Compared with the fasting state, bioavailability is 24% lower, and the peak concentration delayed about 37 min when an 850 mg tablet is administered with food. |
Databáze: |
OpenAIRE |
Externí odkaz: |
|