DNA and modified vaccinia Ankara prime-boost vaccination generates strong CD8
| Autor: | Suzy A, Eldershaw, Hayden, Pearce, Charlotte F, Inman, Karen P, Piper, Ben, Abbotts, Christine, Stephens, Samantha, Nicol, Wayne, Croft, Richard, Powell, Jusnara, Begum, Graham, Taylor, Jane, Nunnick, Donna, Walsh, Mirjana, Sirovica, Shamyla, Saddique, Sandeep, Nagra, Paul, Ferguson, Paul, Moss, Ram, Malladi |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Cytotoxicity Immunologic Male Receptors Antigen T-Cell alpha-beta Vaccination Hematopoietic Stem Cell Transplantation Graft vs Leukemia Effect Vaccinia virus Viral Vaccines Middle Aged Allografts Vaccines Attenuated Minor Histocompatibility Antigens Epitopes Immunogenicity Vaccine Antigens Neoplasm HLA-A2 Antigen Vaccines DNA Humans Gene Rearrangement beta-Chain T-Cell Antigen Receptor Peptides Immunologic Memory Oligopeptides Aged T-Lymphocytes Cytotoxic |
| Zdroj: | British journal of haematologyReferences. 195(3) |
| ISSN: | 1365-2141 |
| Popis: | Allogeneic immune responses underlie the graft-versus-leukaemia effect of stem cell transplantation, but disease relapse occurs in many patients. Minor histocompatibility antigen (mHAg) peptides mediate alloreactive T cell responses and induce graft-versus-leukaemia responses when expressed on patient haematopoietic tissue. We vaccinated nine HA-1-negative donors against HA-1 with a 'prime-boost' protocol of either two or three DNA 'priming' vaccinations prior to 'boost' with modified vaccinia Ankara (MVA). HA-1-specific CD8 |
| Databáze: | OpenAIRE |
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