| Autor: |
Sari, Mattila, Pirjo, Merilahti, Sarah, Wazir, Tania, Quirin, Mirko M, Maksimainen, Yuezhou, Zhang, Henri, Xhaard, Lari, Lehtiö, Tero, Ahola |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Antimicrob Agents Chemother |
| ISSN: |
1098-6596 |
| Popis: |
Alphaviruses are positive-strand RNA viruses causing febrile disease. Macrodomain-containing proteins, involved in ADP-ribose-mediated signaling, are encoded by both host cells and several virus groups, including alphaviruses. In this study, compound MRS 2578 that targets the human ADP-ribose glycohydrolase MacroD1 inhibited Semliki Forest virus production as well as viral RNA replication and replicase protein expression. The inhibitor was similarly active in alphavirus trans-replication systems, indicating that it targets the viral RNA replication stage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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