[Mechanisms of the radiation-induced disorder of DNA synthesis. The correlation of biosynthesis, DNA repair and DNA polymerase alpha and beta activity in the bone marrow of rats exposed to gamma quanta and fast neutrons]

Autor:	L N, Ushenkova, V K, Mazurik, P G, Rubachev
Rok vydání:	1986
Předmět:	Male Neutrons Time Factors DNA Repair DNA Single-Stranded Rats Inbred Strains DNA DNA Polymerase II DNA Polymerase I Rats Fast Neutrons Bone Marrow Gamma Rays Animals Female Relative Biological Effectiveness DNA Damage
Zdroj:	Radiobiologiia. 26(6)
ISSN:	0033-8192
Popis:	A study was made of DNA biosynthesis and repair and alpha- and beta-DNA-polymerase activity in rat bone marrow during the first 24 hours following whole-body irradiation with gamma-quanta and fast neutrons (up to 6 Gy). There was a correlation between the post-irradiation inhibition of DNA biosynthesis, a decrease in DNA-polymerase activity and template reparability. The data obtained permitted to consider the radiation-induced disturbance of DNA biosynthesis and the change in beta-polymerase activity as one of the possible mechanisms of formation of high relative biological effectiveness of neutrons.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a956d738d7149dcc3dc41d16c42734df https://pubmed.ncbi.nlm.nih.gov/3809409 Zobrazit plný text záznamu