| Autor: |
Florian, Mayrhofer, Zhanna, Dariychuk, Anthony, Zhen, Daniel J, Daugherty, Peter, Bannerman, Angela M, Hanson, David, Pleasure, Athena, Soulika, Wenbin, Deng, Olga V, Chechneva |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Neurobiology of disease. 161 |
| ISSN: |
1095-953X |
| Popis: |
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease with high variability of clinical symptoms. In most cases MS appears as a relapsing-remitting disease course that at a later stage transitions into irreversible progressive decline of neurologic function. The mechanisms underlying MS progression remain poorly understood. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. Here we demonstrate that mice that develop mild EAE after immunization with myelin oligodendrocyte glycoprotein 35-55 are prone to undergo clinical progression around 30 days after EAE induction. EAE progression was associated with reduction in CD11c |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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