Clinical Response to Ingenol Mebutate in Patients With Actinic Keratoses

Autor:	A, Batalla, Á, Flórez, C, Feal, G, Peón, M T, Abalde, L, Salgado-Boquete, C, de la Torre
Rok vydání:	2014
Předmět:	Aged 80 and over Male Remission Induction Middle Aged Combined Modality Therapy Medication Adherence Keratosis Actinic Treatment Outcome Scalp Dermatoses Cryotherapy Drug Evaluation Humans Female Drug Eruptions Diterpenes Facial Dermatoses Aged Retrospective Studies
Zdroj:	Actas dermo-sifiliograficas. 106(10)
ISSN:	1578-2190
Popis:	Cryotherapy is the most common treatment for actinic keratosis, but its effect is limited to individual lesions. Several topical drugs, however, are available that, in addition to treating individual actinic keratoses, target field cancerization and thereby act on subclinical lesions. Examples are 5-fluorouracil, imiquimod, diclofenac, and ingenol mebutate. We report on 17 patients with actinic keratoses treated with ingenol mebutate and describe our findings on treatment effectiveness, adherence, and tolerance. Complete and partial response rates were 35% and 53%, respectively. Ninety-four percent of patients fully adhered to treatment and 18% developed severe local reactions. Ingenol mebutate is an effective treatment for actinic keratosis. Although it has a similar rate of local reactions to other treatments available for actinic keratosis, its short treatment regimen favors better adherence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a90f9ebb226e2db58f4cc5653369e8fd https://pubmed.ncbi.nlm.nih.gov/26055975 Zobrazit plný text záznamu Full Text from ScienceDirect