| Autor: |
Ai-Jie, Huang, Xiao-Xia, Hu, Jian-Min, Wang |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 25(1) |
| ISSN: |
1009-2137 |
| Popis: |
Thrombocytopenia is a major complication following allogeneic stem cell transplantation(allo-HSCT). Overall survival(OS) and disease-free survival(DFS) of patients with thrombocytopenia were lower than those without thrombocytopenia. Lower platelet counts before conditioning, graft-versus-host disease(GVHD) and cytomegalovirus(CMV) infection are adverse factors for the patiens with thrombocytopenia. Bone marrow microenvironment may be involved in the pathogenesis. Thrombopoietin(TPO) and mesenchymal stem cells can improve the platelet counts. In this review the definition, prognosis, pathogenesis and potential therapy for thrombocytopenia after allo-HSCT are summarized. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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