Induction of therapeutic levels of HbF in genome-edited primary β

Autor:	Maura, Mingoia, Cristian A, Caria, Lin, Ye, Isadora, Asunis, M Franca, Marongiu, Laura, Manunza, M Carla, Sollaino, Jiaming, Wang, Annalisa, Cabriolu, Ryo, Kurita, Yukio, Nakamura, Francesco, Cucca, Yuet W, Kan, M Giuseppina, Marini, Paolo, Moi
Rok vydání:	2020
Předmět:	Gene Editing HEK293 Cells beta-Thalassemia Humans CRISPR-Cas Systems Hematopoietic Stem Cells K562 Cells Cells Cultured Fetal Hemoglobin Up-Regulation
Zdroj:	British journal of haematologyReferences. 192(2)
ISSN:	1365-2141
Popis:	Hereditary persistence of fetal haemoglobin (HPFH) is the major modifier of the clinical severity of β-thalassaemia. The homozygous mutation c.-196 CT in the Aγ-globin (HBG1) promoter, which causes Sardinian δβ
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a8e4b16955645de8560b0a91220a72f2 https://pubmed.ncbi.nlm.nih.gov/33216968 Zobrazit plný text záznamu Plný text