Synthesis, radiotechnetium labelling, and comparison of biologic behavior of longer-chain analogs of methylene diphosphonate

Autor:	T S, Wang, P, Hosain, R P, Spencer, K, Ahlquist, F, Hosain
Rok vydání:	1978
Předmět:	Mice Structure-Activity Relationship Diphosphonates Isotope Labeling Animals Technetium Tissue Distribution Rabbits Bone and Bones
Zdroj:	Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 19(10)
ISSN:	0161-5505
Popis:	Polymethylene diphosphonic acids of different chain lengths ( n = 2, 3, and 10) were synthesized and labeled with technetium-99m. Their biologic behavior was compared with that of Tc-99m-labeled methylene diphosphonate (MDP) in experimental animals. With n = 2 (ethylene diphosphonic acid), the compound resembled MDP in bone affinity. The longer-chain analogs had lower bone affinity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a8cccc447883e2cf4c1afc324b8107f2 https://pubmed.ncbi.nlm.nih.gov/722328 Zobrazit plný text záznamu