Elevated stromal chondroitin sulfate glycosaminoglycan predicts progression in early-stage prostate cancer
| Autor: | C, Ricciardelli, K, Mayne, P J, Sykes, W A, Raymond, K, McCaul, V R, Marshall, W D, Tilley, J M, Skinner, D J, Horsfall |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Aged 80 and over Male Time Factors Adolescent Chondroitin Sulfates Prostate Antibodies Monoclonal Prostatic Neoplasms Cell Differentiation Middle Aged Prostate-Specific Antigen Prognosis Immunohistochemistry Survival Analysis Disease-Free Survival Biomarkers Tumor Disease Progression Humans Stromal Cells Cell Division Aged Neoplasm Staging |
| Zdroj: | Clinical cancer research : an official journal of the American Association for Cancer Research. 3(6) |
| ISSN: | 1078-0432 |
| Popis: | Curative therapies for clinically localized prostate cancer have significant morbidity, and those patients who might be cured by aggressive management are not easily identified using current clinical information. Better biomarkers of tumor behavior need to be identified to improve clinical outcome. Chondroitin sulfate (CS), a glycosaminoglycan, may be a potentially useful biomarker as it is known to influence cell growth and differentiation and might influence malignant progression. In this study, CS was immuno-localized to the periacinar and peritumoral fibromuscular stromal tissue of nonmalignant and malignant prostates. The CS concentration was increased in the prostate tissue of men with early-stage prostate cancer compared with tissue from men without cancer (P0.0001). Using Cox's univariate analysis, CS concentration, tumor grade, preoperative serum prostate-specific antigen (PSA), extracapsular extension of disease, positive surgical margins, and patient age were associated with an increased risk of PSA failure. The CS concentration was compared with the other features in two-variable regression analyses. CS and preoperative serum PSA concentrations were independent predictors of PSA failure. CS was a stronger prognostic feature than tumor grade and could predict outcome for patients with moderately differentiated tumors. Patients with a low CS concentration had significantly better progression-free survival following radical prostatectomy than patients with high levels of CS (Kaplan-Meier plot, 91% versus 49% PSA progression free at 5 years, respectively, P = 0.0038). Only postoperative pathological indices (extracapsular extension, surgical margins) were stronger predictors than CS. We conclude that measurement of prostatic CS concentrations at diagnosis may allow stratification of patients with early-stage prostate cancer for adjunctive or alternate therapies. |
| Databáze: | OpenAIRE |
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